Hepatic Lipidosis
Hepatic lipidosis is the most common liver disease in cats, characterized by excessive accumulation of triglycerides within hepatocytes. It typically develops when an overweight or obese cat stops eating for as few as 2-7 days. The liver becomes overwhelmed by mobilized fat, leading to liver failure. It can be primary (idiopathic) or secondary to another disease.
Symptoms & Signs
- Complete loss of appetite (anorexia)
- Rapid weight loss
- Jaundice (yellow skin, gums, eyes)
- Vomiting
- Lethargy and depression
- Drooling
- Hepatomegaly (enlarged liver)
- Coagulopathy in severe cases
Causes & Risk Factors
Triggered by anorexia (any cause) in cats, especially overweight cats. The cat's unique lipid metabolism leads to excessive fat mobilization to the liver when food intake stops. Primary: idiopathic anorexia. Secondary: underlying disease causing appetite loss (pancreatitis, IBD, cholangitis, stress).
Diagnosis
Blood work: elevated liver enzymes (ALP, GGT, bilirubin), low albumin. Ultrasound: hyperechoic liver. Fine needle aspirate showing >50% of hepatocytes containing fat vacuoles. Identification of underlying cause if secondary.
Treatment
Aggressive nutritional support via feeding tube (esophagostomy or nasogastric) for 4-6 weeks. High-protein, calorie-dense diet. Anti-nausea medications. Vitamin supplementation (B12, K, E). L-carnitine and SAMe. Treatment of underlying cause. IV fluids for dehydration.
Prevention
Never allow cats to go without food for >24-48 hours. Gradual weight loss programs for obese cats (1-2% body weight per week maximum). Monitor appetite during stressful events. Prompt veterinary attention for any cat not eating.
Prognosis
With aggressive nutritional support: 60-80% survival rate. Without treatment: fatal. Recovery takes 4-8 weeks of tube feeding. Cats that survive typically make full recovery with no permanent liver damage.
Affected Breeds (3)
| Breed | Species | Size |
|---|---|---|
| Blue-fronted Amazon | Bird | Medium |
| Pacific Parrotlet | Bird | Small |
| African Pygmy Hedgehog | Small Mammal | Tiny |