Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) is a group of chronic gastrointestinal disorders characterized by persistent inflammation of the intestinal wall by inflammatory cells (lymphocytes, plasmacytes, eosinophils). It is a diagnosis of exclusion, made after ruling out other causes of chronic GI signs. The condition likely represents an inappropriate immune response to dietary or microbial antigens.
Symptoms & Signs
- Chronic vomiting
- Chronic diarrhea (small or large bowel pattern)
- Weight loss
- Decreased appetite
- Increased flatulence
- Borborygmi (stomach gurgling)
- Blood or mucus in stool
- Poor coat condition
Causes & Risk Factors
Multifactorial: genetic predisposition, dietary antigen sensitivity, dysbiosis (altered gut microbiome), and dysregulated mucosal immune response. Environmental factors and stress may trigger or exacerbate. Certain breeds predisposed (Basenji, German Shepherd, Soft-Coated Wheaten Terrier).
Diagnosis
Diagnosis of exclusion: rule out parasites, dietary intolerance, infections, and other causes. Intestinal biopsy (endoscopic or full-thickness surgical) with histopathology is definitive. Blood work may show hypoalbuminemia, elevated folate/cobalamin abnormalities.
Treatment
Dietary management (novel protein or hydrolyzed diet). Immunosuppressive therapy (prednisolone, budesonide, chlorambucil, azathioprine). Probiotics and prebiotics. Cobalamin supplementation if deficient. Fecal microbiota transplantation (emerging).
Prevention
No proven prevention. High-quality diet, probiotic supplementation, and stress reduction may help maintain gut health. Early intervention at first signs of chronic GI disease.
Prognosis
Most dogs and cats can be well-managed with appropriate diet and medication. Some achieve remission on diet alone. Protein-losing enteropathy (severe form) carries a more guarded prognosis. Lifelong management typically required.