Hepatic Moderate to Severe Hereditary DogCat

Portosystemic Shunt

Also known as: PSS, Liver Shunt, Hepatic Shunt

A portosystemic shunt (PSS) is an abnormal blood vessel that allows blood from the intestines to bypass the liver, entering systemic circulation without hepatic detoxification. This results in accumulation of toxins (ammonia, mercaptans) that affect the brain (hepatic encephalopathy). Shunts can be congenital (single vessel) or acquired (multiple vessels from portal hypertension).

Symptoms & Signs

Causes & Risk Factors

Congenital: failure of the fetal ductus venosus to close or development of anomalous vessels. Genetic predisposition in certain breeds (Yorkshire Terrier, Maltese, Irish Wolfhound, Havanese). Acquired: secondary to chronic liver disease causing portal hypertension.

Diagnosis

Blood work: low BUN, low albumin, low glucose, microcytosis. Bile acids (pre and post-prandial) markedly elevated. Ammonia levels elevated. Abdominal ultrasound or CT angiography to visualize the shunt vessel. Portography for surgical planning.

Treatment

Surgical: ameroid constrictor or cellophane banding for gradual shunt closure. Medical management: low-protein diet, lactulose (reduces ammonia absorption), antibiotics (metronidazole, neomycin). Interventional radiology (coil embolization) at specialized centers.

Prevention

Genetic screening and responsible breeding in affected breeds. No environmental prevention for congenital shunts. Early detection through routine blood work in predisposed breeds.

Prognosis

Surgical correction: excellent long-term outcomes (>85% good-excellent). Medical management alone: fair, with progressive liver disease over time. Acquired multiple shunts: guarded, as they indicate advanced liver disease.

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