Hematologic Mild to Severe Hereditary Dog

Von Willebrand Disease

Also known as: vWD, Von Willebrand's Disease

Von Willebrand Disease (vWD) is the most common inherited bleeding disorder in dogs, caused by deficiency or dysfunction of von Willebrand factor (vWF), a protein essential for platelet adhesion and blood clot formation. Three types exist: Type 1 (most common, partial quantitative deficiency), Type 2 (qualitative deficiency), and Type 3 (complete absence, most severe).

Symptoms & Signs

Causes & Risk Factors

Inherited mutations in the vWF gene. Type 1: autosomal dominant with incomplete penetrance (Doberman, Shetland Sheepdog). Type 2: autosomal recessive (German Shorthaired Pointer). Type 3: autosomal recessive (Scottish Terrier, Shetland Sheepdog).

Diagnosis

vWF antigen level measurement (normal >70%, borderline 50-70%, abnormal <50%). Buccal mucosal bleeding time (BMBT) assesses clinical significance. DNA testing available for many breed-specific mutations. Coagulation panel typically normal.

Treatment

Desmopressin (DDAVP) increases vWF release temporarily (Type 1 only). Cryoprecipitate or fresh frozen plasma for active bleeding or pre-surgical preparation. Avoid medications that impair platelet function (NSAIDs, aspirin). Aminocaproic acid as adjunct.

Prevention

DNA testing of breeding stock. Removing affected dogs from breeding programs. Pre-surgical screening in at-risk breeds. Informing veterinarians of vWD status before any procedure.

Prognosis

Type 1: generally good; most dogs live normal lives with precautions during surgery. Type 2: moderate; more significant bleeding risk. Type 3: guarded; severe bleeding episodes can be life-threatening.

Affected Breeds (5)

BreedSpeciesSize
Bernese Mountain DogDogGiant
Doberman PinscherDogLarge
Pembroke Welsh CorgiDogMedium
Scottish TerrierDogSmall
Shetland SheepdogDogSmall

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