Von Willebrand Disease
Von Willebrand Disease (vWD) is the most common inherited bleeding disorder in dogs, caused by deficiency or dysfunction of von Willebrand factor (vWF), a protein essential for platelet adhesion and blood clot formation. Three types exist: Type 1 (most common, partial quantitative deficiency), Type 2 (qualitative deficiency), and Type 3 (complete absence, most severe).
Symptoms & Signs
- Prolonged bleeding from wounds or surgery
- Nosebleeds (epistaxis)
- Blood in urine (hematuria)
- Bleeding gums
- Bruising easily
- Excessive bleeding during heat cycles
- Gastrointestinal bleeding
Causes & Risk Factors
Inherited mutations in the vWF gene. Type 1: autosomal dominant with incomplete penetrance (Doberman, Shetland Sheepdog). Type 2: autosomal recessive (German Shorthaired Pointer). Type 3: autosomal recessive (Scottish Terrier, Shetland Sheepdog).
Diagnosis
vWF antigen level measurement (normal >70%, borderline 50-70%, abnormal <50%). Buccal mucosal bleeding time (BMBT) assesses clinical significance. DNA testing available for many breed-specific mutations. Coagulation panel typically normal.
Treatment
Desmopressin (DDAVP) increases vWF release temporarily (Type 1 only). Cryoprecipitate or fresh frozen plasma for active bleeding or pre-surgical preparation. Avoid medications that impair platelet function (NSAIDs, aspirin). Aminocaproic acid as adjunct.
Prevention
DNA testing of breeding stock. Removing affected dogs from breeding programs. Pre-surgical screening in at-risk breeds. Informing veterinarians of vWD status before any procedure.
Prognosis
Type 1: generally good; most dogs live normal lives with precautions during surgery. Type 2: moderate; more significant bleeding risk. Type 3: guarded; severe bleeding episodes can be life-threatening.
Affected Breeds (5)
| Breed | Species | Size |
|---|---|---|
| Bernese Mountain Dog | Dog | Giant |
| Doberman Pinscher | Dog | Large |
| Pembroke Welsh Corgi | Dog | Medium |
| Scottish Terrier | Dog | Small |
| Shetland Sheepdog | Dog | Small |